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Moreover, aged NKCC2A KO male mice developed overweight and consumed excessive food and water indicating that, unsurprisingly, the kidneys and other organs may contribute to the impaired glucose homeostasis observed in NKCC2A KO mice (Kelly et al., 2019)

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325 GIPR is downregulated in adipose tissue during insulin-resistant states, such as obesity, and several studies suggest that GIP augments insulin actions in adipose tissue