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Some patients may require longer treatment depending on their goals, their starting weight, and individual differences in metabolism
The effect remains gradual and cumulative rather than instant
GLP-1 receptor (GLP-1R) activation Stimulates insulin release and suppresses glucagon secretion Delays gastric emptying Provides central appetite regulation Exhibits biased signaling favoring cAMP over -arrestin recruitment sustained receptor expression and enhanced insulin secretory capacity Benefits include: \Weight Loss: Up to 22.5% reduction in body weight
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Genetic variants in the GLP1R gene (e.g., rs6923761), GIPR receptor (rs1800437), FTO (rs9939609), and MC4R (rs17782313) influence appetite signaling, energy expenditure, and medication responsiveness
