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Medical Factors That Undercut Dieting Hormone signaling drift: Imbalances in ghrelin, leptin, and insulin can heighten hunger, reduce satiety, and push the body to store fat

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In a comparative study of the herbicide oxadiazon, a xenobiotic with peroxisome proliferative activity but structurally distinct from other peroxisome proliferators, in Sprague-Dawley rats, CD1 mice, and Beagle dogs, treatment for fourteen (rats) or twenty-eight (mice and dogs) days produced liver enlargement in all three species (Richert et al