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They noted that while the prior study involved patients referred to a single major medical center in a city with a high degree of medical sophistication, our study included individuals from a more general clinical setting. Additionally, they pointed out that differences in population characteristics and drug prescription preferences between single institutions and global databases may contribute to varying results, as can differences in healthcare systems across regions and countries

Faillie JL, Yin H, Yu OHY, et al

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In both groups the mean age and diseases duration resulted higher than the overall population of the main RCT studies [25, 26], which could derive from an older diabetic population in Italy than in other countries [27]