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Some of the change may be related to shifts in fluid balance or other tissues

P-31 NMR changes in Alzheimer's and Huntington's disease brain Neurology 1984

These findings and interpretations are indirectly supported by a recent report on fatigue in the long COVID-19 syndrome where lower peripheral serotonin was observed in patients than in healthy controls (5)

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Mitochondrial isolation followed by immunoblotting confirmed that SLC25A39 protein was enriched in mitochondrial fractions, as indicated by the mitochondrial marker COX IV, with no contamination from cytoplasmic -actin