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Pathways for the biosynthesis of secondary metabolites use precursors synthesizes during glycolysis, the tricarboxylic acid cycle and the pentose-phosphate pathway [18]

This makes RPE responsive to multiple peptide types

Researchers have also examined its effects on gut epithelial and endothelial models in the context of gastrointestinal barrier research (Sikiric et al., 2025, Pharmaceuticals)

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Enhances Skin Barrier Function GHK-Cu reinforces the epidermal barrier, improving: Moisture retention Protection from environmental stressors Resilience against irritants This strengthens the skins natural defenses and reduces transepidermal water loss