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In studies examining diet composition effects, Melanotan II most strongly inhibited caloric intake in rats consuming high-fat diets, with fat intake being the most suppressed dietary component

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Animals in the LOsG and sham groups ( n = 10 in both groups) were given 6 g/kg glucose and distilled water (2 mL/100 g body weight), respectively, by gavage every 6 h for 6 weeks

However, they were comparing exenatide and liraglutide to placebo and other diabetes medications that lower glucose levels

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