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Mattes-Kulig 1985)

Endothelial cells associated with tumors secrete growth factors such as vascular endothelial growth factor (VEGF), Notch ligands, and nitric oxide, which enables the cancer cells proliferation and self-renewal (127)

This review provides an overview of the mechanistic functions, interrelated processes, and therapeutic implications of several programmed cell death (PCD) pathwaysincluding apoptosis, pyroptosis, necroptosis, autophagy, and ferroptosisin the context of TNBC pathogenesis and treatment

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