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Both drugs, particularly higher doses of tirzepatide, increased gastrointestinal adverse events

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The first injection at each new dose level, when you step from 2.5 to 5 mg, or from 5 to 7.5 mg, tends to produce the strongest nausea within that tier

Common side effects include nausea, diarrhea, constipation, and mild itching around the injection site

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This produces a final concentration of 1 mg per 1 ml , so every 0.10 ml drawn into a U-100 insulin syringe contains 0.10 mg of semaglutide