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It is not recommended for use in pregnant women, breastfeeding women and children (below 15 years of age)

Research findings are mixed: Some studies suggest benefit in neurological conditions, while reviews have raised questions about the strength, consistency, and quality of evidence

Endocrinology and Metabolism Clinics of North America, 43(1), 75-102

Although the difference fell short of statistical significance ( P =0.16), there was a significant difference in scores for disease activity, the group reported in ACR Open Rheumatology

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