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However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research

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Pouchieu, C., Pourtau, L., Brossaud, J., Gaudout, D., Corcuff, B., Capuron, L., Castanon, N., & Philip, P

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