In life-threatening cases, 5,000,000mcg of B12 is given directly to the veins within a 15 minute window
Babula JJ, Bui D, Stevenson HL, et al
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Factors such as your metabolism, genetic predisposition, lifestyle habits (like diet, exercise, and sleep), and individual response to B12 can all influence the timeline for experiencing improvements
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"Conformational changes on substrate binding to methylmalonyl CoA mutase and new insights into the free radical mechanism"