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The WNK2 gene is located on chromosome 9q22.31 and is composed of 38 exons that generate two alternatively spliced mRNAs both of which encode distinct protein isoforms
The effectiveness of tirzepatide for treating obesity is being evaluated in the SURMOUNT series of phase 3 RCTs, which, for the first time, demonstrated average weight reductions exceeding 20% with pharmacotherapy [23]
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