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The question: does sustained elevation of intracellular NAD+ via NNMT inhibition produce the same long-term benefits as NAD+ precursor supplementation (like nicotinamide riboside or NMN), or are there trade-offs we haven't identified yet
Adherence matters because missed doses can reduce benefit and complicate assessment, so clear schedules and reminders are useful
doi: 10.1053/j.gastro.2021.12.282 24 CowardSClementFBenchimolEIBernsteinCNAvina-ZubietaJABittonAet al
Bhatti JS, Bhatti GK, Reddy PH (2017) Mitochondrial dysfunction and oxidative stress in metabolic disorders a step towards mitochondria based therapeutic strategies
You need to decide how much BAC water to add
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