The number of studies examining newer medicines like semaglutide and tirzepatide remains relatively small, and follow-up durations after stopping medicines were generally short, meaning some estimates are modelled projections beyond observed follow-up
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Genetic variants in the GIPR gene, FTO gene (metabolic efficiency), and MC4R gene (appetite center signaling) all contribute to how long you'll benefit from continuous semaglutide therapy before reaching a plateau