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doi:10.1056/NEJMoa2107519 140

Ongoing studies continue to examine dual-pathway growth hormone stimulation, endocrine regulation, IGF-1 physiology, receptor signaling, and the coordinated biology of the hypothalamic-pituitary axis

These residues are located at the base of the GLP-1R binding pocket in the cryo-EM structures and interact with residues in TMs 1, 2 and 7 (Figs