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**Weeks 17+: 12mg (if needed)** -- Maximum dose

Our findings offer comprehensive real-world evidence for the cardiovascular effectiveness of tirzepatide in clinical practice in the absence of studies with direct comparisons to semaglutide, and ahead of further evidence from the SURPASS-CVOT randomized controlled trial that compared tirzepatide against an older GLP-1 receptor agonist that is not frequently used in routine care 14,17

Victoza (liraglutide) Summary of Product Characteristics

The reduction in BW and the improved GC are important factors in reducing NAFLD parameters, reducing hepatic steatosis and fibrosis (93) and improving hepatic necro-inflammation (94, 95)

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Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome