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This is a higher standard of oversight
They are typically given as a once-weekly injection
And you may further rationalize, well if they do shut them down, at least they wont come after me
Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans
60% achieved at least 20% weight loss and 23% lost 30% or more
Your provider can discuss this switch after confirming that dietary modifications and smaller meals have not relieved your symptoms
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