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GLP-1RAs are generally recommended for patients with T2D whose glycated haemoglobin (HbA 1c ) is above target despite diet, exercise and existing glucose-lowering medication, and GLP-1RAs with proven cardiovascular benefit are also recommended in patients with T2D at elevated cardiovascular risk, regardless of HbA 1c [5, 6]
If you're on a high dose of semaglutide near the top-end of what the manufacturers recommend, or even more if you're going off-label with compounded semaglutide then you may experience more of a drop from missing a dose, especially if you don't notice right away
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