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Phase 2 subjects on 150mg/day averaged 13.8% weight loss with no muscle loss reported

Homozygous UGT1A1*28 causes Gilbert syndrome , a benign condition affecting 5-10% of the population characterized by intermittent unconjugated hyperbilirubinemia (elevated indirect bilirubin) triggered by fasting, stress, illness, or menstruation

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Medications like tirzepatide and semaglutide improve insulin sensitivity and reduce chronic inflammation