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Given that appetite and weight control will be key targets for an oral formulation, it is fortuitous that it is the stimulation of vagal afferents that has a direct impact on satiety effects of GLP1-RAs ( Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author

42 The effects of GLP-1 RAs in HFrEF have been studied in several small trials

doi: 10.3892/etm.2020.9124 233 SongAFKangLWangYFWangM

Yilan Huang, [email protected] These authors share first authorship These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Laakso, M., & Fernandes Silva, L

however none were approved for use (Huttunen and Rautio, 2011)