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Rapid weight loss is generally not recommended

oral GLP-1s Unlike small molecules, biological therapies such as GLP-1 analogs are administered via weekly subcutaneous or intravenous injections

Hypoglycemia (Low Blood Sugar): The risk is low when GLP-1s are used alone but increases significantly when they are combined with other diabetes medications like insulin or sulfonylureas

Contraindications include known hypersensitivity to mannitol (present in the formulation), active malignancy, pregnancy, disruption of the hypothalamic-pituitary axis (after surgery, radiation or major trauma), and severe hypersensitivity to any component of the lyophilized product

They are given as weekly injections through pre-filled pens that are administered into the upper arm, thigh or stomach

Comparing Oral vs