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In this section, we will discuss the signs that a vial is no longer good to use, how improper storage can affect the medication, and what to do if you think a vial has gone bad

Journal of Sex Research, 56 (7), 882898

A gradual loss of efficacy, where the same dose produces less appetite suppression or fewer effects than it used to, can also indicate degradation if all other variables have remained constant

In the SURMOUNT-5 trial, tirzepatide produced an average weight reduction of 20.2% (about 50 lbs) over 72 weeks, compared with 13.7% (about 33 lbs) for injectable semaglutide

Recent guidance from endocrinology societies emphasizes the importance of tailoring therapy to individual risk profiles, including cardiovascular and renal considerations

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