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Lut attenuates the levels of inflammatory cytokines and reduces oxidative stress in the kidneys of mice with IgAN As shown in Figure 2D, the secretion of TNF-, IL-1, and IL-6 was markedly increased in IgAN mice, whereas Lut treatment significantly reduced the levels of these proinflammatory cytokines compared with those in the IgAN group
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Therefore, neuronal subsets (iSPNs) from mouse striatal tissues of mutants and controls (here called iSPN + mut and iSPN + wt populations, respectively) were genetically labelled in vivo with a fluorescent marker using Rosa26-Ai9-tdTomato strain 21 and purified by fluorescence-activated cell sorting
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