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A structural model of the interaction suggests that the active molecule is a hydrolyzed form of PL (hPL) which forms a complex with GSH in the enzyme active site

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The term apheresis, often used to describe TPE, came from that experiment

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A robust and validated LC-MS/MS method was used to evaluate the ability of the in vitro iPSC-hBBB model to discriminate between CNS and non CNS drugs (Table 1)