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By comparing the metabolic pathway activities for the gdh3 / gdh3 mutant grown on arginine medium as opposed to on proline medium with the wild-type strain under those growth conditions, there was a greater global metabolic reprogramming for the wild-type cells when grown on arginine compared to growth on proline (Fig

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However, TNF alpha inhibitors may trigger additional lupus features, leading to a diagnosis of TAILS

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The condition typically progresses through inflammatory, frozen, and thawing phases over 12 to 24 months