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DPP-4 inhibitors do not have significant effects on GI motility or appetite that are observed with more efficacious (DPP-4 resistant) GLP-1 agonists

Open research questions Important gaps remain in the literature

As illustrated in Figure 5 , a significant increase in Fat-Free Mass Index was observed as early as T3 compared with T0, and the increase, although no longer significant, was confirmed until the end of the follow-up

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Similarly, a small-scale sgRNA competition assay in HEK-293T SLC25A39 knockout and control cells infected with a pool of control and SLC25A40 sgRNAs confirmed these results under BSO treatment (Extended Data Fig