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Over the following 30 years, more than 130 peer-reviewed papers have followed, the vast majority from his group and primarily in animal models

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In 1980 Jean-Pierre Raufman, a young gastroenterologist (figure 33), and John Pisano, a biochemist at the National Institute of Health with a fascination for venoms, began investigating the effect of peptides found in the saliva of the lizard on human physiology

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This protective effect is mediated through the solute carrier family 38 member 9 (SLC38A9)-mechanistic target of rapamycin kinase (MTOR) axis, which coordinates cholesterol sensing and signaling with the upregulation of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), key ferroptosis suppressors [60]

While KAP involves an IV infusion, it's a distinct therapeutic program