Paul MS, Abhilash M, Varghese MV, Alex M, Harikumaran Nair R
Nausea (most common, ~2044% in clinical data), diarrhea, vomiting, and constipation usually mild and fading after 48 weeks
That fancy term means that these medications imitate the GLP-1 hormone, which regulates the bodys blood sugar levels, promotes insulin secretion, and reduces glucagon, a hormone that raises blood sugar
STEP-1 reported a mean body-weight reduction of about 14.9% at 68 weeks of intervention with semaglutide 2.4 mg weekly vs placebo
Weight gain of 25 kg in the first month is typical, even in caloric deficit, due to glycogen retention and increased fluid volume
Your best choice depends on how you manage routine, side effects, costs, and whether you can combine medication with good habits that preserve muscle and hydration