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For patients using subcutaneous GHK-Cu, this systemic copper depletion compounds the direct competition: zinc can displace copper from weaker chelates, and while GHK's binding constant is high, sustained zinc excess shifts equilibrium unfavorably

A PubMed search limited to clinical trial pubs found no results

A number of studies have shown that taking collagen supplements may improve skin hydration and elasticity and reduce the appearance of wrinkles

Secondly, high doses are generally needed to achieve even moderate increases in Vitamin D levels

By applying GHK-Cu topically, the skin receives a powerful signal to rejuvenate and repair itself

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