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5-Oxoprolinuria can also be caused by mutations in 5-oxoprolinase (OPLAH), a quite rare disease presenting with a high clinical variability

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A failure in the food system post-WWII with dependence on intensified agricultural methods and other environmentally destructive practices has been proposed to be at the root of the rise in mood disorders, with the surge in mental illness metaphorically described as a hidden hunger.21 Nutritional insults that deprive the brain of the nourishment it needs include an energy-dense, highly processed food diet, high glycemic load, and proinflammatory fats (eg, high ratio omega-6s:omega-3s)

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