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Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy

2024 Jul 23;386:q1645

335 In experimental settings, conditional knockout of K ir 4.1 results in epileptic phenotype

Other Ingredients: Diluent[INS 460(i), Lactose Monohydrate), Disintegrant (INS 468, Polacrilin Potassium, Sodium Starch Glycolate), L-Ascorbic Acid, Binder (INS 1201), Glidant [INS 553(i)], Coating Agent (INS 464), Anti sticking Agent [INS 470(iii)], Anticaking Agent (Magnesium Aluminometasilicate), Colour (INS 124), Solubilizer (INS 433), Vehicle (INS 1521), Coating Agent (INS 462), Colour (Titanium Oxide)

Using systems biology and in vitro experiments, this study defined minimal growth requirements, supporting its ecological specialization in the gut mucosa

Although there were no statistically significant differences in DFS and OS between the radiotherapy and ALND groups over a ten-year follow-up, the primary endpoint, the 5-year axillary recurrence rate, was significantly higher in the SLNB group compared to the ALND group, failing to meet the predefined non-inferiority margin