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This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult

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This can potentially reduce the risk of re-injury and help individuals return to their regular activities more quickly

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in particular with concomitant gastroduodenal pathology;cardiac disturbances;depressive disturbances;Parkinson's disease and Parkinson's disease-like pathology;temperature disturbances;bone impairments;hypertension-induced various organ damages;disturbances of coagulation;pain disturbances;convulsion disorders;spinal cord injury;alcohol injuries, induced by alcohol abuse or increased alcohol intake;brain ischemic disorders;peripheral nerve injuries;cataleptic disorders and neuroleptic disturbances;disorders related to abnormal or mutant lymphocytes;disturbances of fetuses;vaginal atrophy and osteoporosis development caused by ovariectomy conditions;tumors;viral diseases, in particular AIDS or ARC;gastrointestinal lesions;cognitive disorders;withdrawal disturbances;kidney disturbances anddisturbances in cellular immune response

doi: 10.1007/BF00004358 94 MingarroMVegaRubn de CelisSAstolaAPendnCValdiviaMMPrezSnchezJ