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Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

Scholz D, Pltl D, Genewsky A, Weng M, Waldmann T, Schildknecht S, et al

Key findings from SURMOUNT-1 include a mean weight loss of 15.0% at the 5mg dose, 19.5% at the 10mg dose, and 20.9% at the 15mg dose over 72 weeks

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No withdrawals due to adverse effects

As for the mechanisms of hypotensive effect beyond BW, augmentation of natriuresis by inhibiting sodium hydrogen exchanger at proximal tubule, ameliorating angiotensin II activity, and enhancing vasodilation can be postulated