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When calcium levels decline (whether from inadequate intake, increased losses, or accelerated bone turnover), parathyroid hormone (PTH) activates as an emergency response, defending serum calcium through bone mobilization, reduced urinary loss, and increased intestinal absorption

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Patients with diabetic retinopathy should be monitored carefully, and severe gastrointestinal symptoms may lead to dehydration and acute kidney injury in susceptible individuals

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The spacing allows the collagen remodeling cycle to progress between sessions