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The core defect is insulin resistance, which raises insulin levels
Muscle is critical for blood sugar regulation, metabolic resilience, strength, mobility, and healthy aging
Flavonoids have limitations with their structure, nature, absorption, molecular weight, toxic flavonoid-drug interactions and high first pass metabolism leading to their reduced bioavailability, therefore, by incorporating them into an effective nanocarrier system these challenges can be overcome (Caro-Ordieres et al
Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury
Acknowledgements This work was supported by the NIA (R00AG037574 and R56AG052981), the Prevent Cancer Foundation, the American Institute for Cancer Research (AICR), the American Federation for Aging Research (AFAR) and Einstein Startup Funds to D.M.H
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