Some preclinical work explores FOXO4-p53-targeting peptides against senescent cancer cells, and the developer has discussed cancer as a research interest, but there is no human evidence that FOXO4-DRI treats cancer
Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and should not be used during pregnancy due to potential fetal harm
Second, among other possible considerations, is to avoid using any non-GLP-1RA antidiabetic drug class as the unexposed group
For example, while there is evidence to suggest that bromelain, one of the components, can influence fat cells and fat breakdown, this work was conducted in a mouse cell model
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doi: 10.1007/s13679-023-00534-z 61 ColbergSRSigalRJYardleyJERiddellMCDunstanDWDempseyPCet al