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Animal studies by Carla Nasca, a postdoctoral scholar in McEwens lab, suggest that acetyl-L-carnitine, a crucial mediator of fat metabolism and energy production throughout the body, plays a special role in the brain, where it works at least in part by preventing the excessive firing of excitatory nerve cells in brain regions called the hippocampus and frontal cortex

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Its potential benefits stem from its role in intracellular signaling pathways that influence insulin sensitivity and ovarian function mechanisms that underlie many of the outcomes studied in clinical research.7 12 15 17 Although inositol is often associated with PCOS, much of the research points to metabolic signaling as the common thread, with reproductive and fertility-related benefits often building on those effects

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Parasitol Today 9: 162166