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They are frequently investigated together because their potential mechanisms of action are thought to be complementary, creating a synergistic effect that is a popular subject of preclinical studies

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Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study

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When IGF-1 axis is activated, multiple signaling pathways corresponding to its kinase domain are also activated, including PI3K/Akt pathway and Raf/MEK/ERK level linkage pathway, which can ultimately reduce IR and prevent cell apoptosis (58, 59), thereby improving NAFLD