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Underlying cardiovascular disease: Many patients prescribed GLP-1 medications have cardiovascular risk factors or established heart disease

The ideal temperature is between 2C and 8C (36F and 46F)

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Consider whether you can commit to permanent lifestyle changes, long term medication use and regular monitoring

Some clinicians prefer to reduce the dose stepwise (for example, moving from a higher to lower maintenance dose before stopping completely) to allow for metabolic adjustment and medication changes

doi: 10.1186/s12967-016-0985-7 39