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AMG 133 results in full agonism of human GLP-1R (EC 50 = 24.4 pM) and activated cynomolgus monkey and mouse GLP-1R (EC 50 of 5.7 and 123 pM, respectively)
For researchers studying these pathways, having access to consistent, high-purity compounds is paramount
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Giloteaux L, Hanson MR, Keller BA
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It has since received significant attention for its weight loss efficacy, with Zepbound (Tirzepatide for obesity) receiving separate FDA approval in 2023
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