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The most commonly reported side effects are mild and transient: injection site redness or minor bruising, transient fatigue in the first one to two weeks, and occasionally mild headache following the first few injections, a pattern sometimes attributed to the acute shift in cellular energy metabolism as AMPK pathways are upregulated [3]

[1] Other safety considerations include risk of gallbladder disease, pancreatitis, diabetic retinopathy complications (particularly with rapid A1c reduction), and hypersensitivity reactions

Additionally, one clinical trial by Douglas Greig et al

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PS, performance status

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