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Generally, after 812 weeks of continuous use, a 4-week washout period is required to avoid tolerance from long-term continuous use

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During pregnancy, the recommended amount increases to 2.6 mcg and when breastfeeding, to 2.8 mcg

Research Use Only Disclaimer Research Use Only: The materials and studies discussed in this article are presented solely for scientific and informational review

I was curious but never really got in to it at that point