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Mattson, 2007

GLP-1 (glucagon-like peptide-1) agonists are not just another diet pill

demonstrated that GLP-1/GLP-1R signalling plays a crucial role in activating signal transducer and activator of transcription 3 (STAT3), which directly promotes human M2 macrophage polarization while inhibiting classically activated M1 macrophages, known for their pro-inflammatory and tissue-destructive properties (44)