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The no observed adverse effect level (NOAEL) was determined to be 540 mg/kg, equivalent to 24 times the human clinical dose (448 mg/person/28 days), supporting the safety margin of rotigotine behenate loaded in PLGA microspheres and its potential for advancement into phase I clinical trials for PD 137
Limit of quantification (LOQ), on the other hand, is the lowest concentration or amount of an analyte that can be accurately and precisely quantified by an analytical method with a certain degree of confidence
freeze-dried, solutions or dispersions AHUMAN NECESSITIES A61MEDICAL OR VETERINARY SCIENCE
J Control Release
These sharp crystals can physically shear and fracture the delicate peptide chains, a process known as mechanical degradation
Regular application is crucial
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