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Toxins (Basel)

Patients should contact their GP or diabetes team if they experience: Severe, persistent abdominal pain (potential pancreatitis) Persistent vomiting leading to dehydration Signs of hypoglycaemia (if taking alongside insulin or sulphonylureas) Severe or persistent constipation or abdominal distension Right upper quadrant pain, fever or jaundice (potential gallbladder problems) Sudden visual changes (especially in those with diabetic retinopathy) Allergic reactions or injection site problems Weight loss typically becomes noticeable within the first few weeks to months, though the rate varies considerably between individuals

All of the drugmakers face the prospect of more local competition in China, where Novo's patent on Wegovy's active ingredient semaglutide expires in 2026 and companies like CSPC Pharmaceutical Group and Hangzhou Jiuyuan Genetic Biopharmaceutical Co are developing their own versions of the drug

Consult with your doctor if you are experiencing severe side effects after taking Ozempic long-term

Rubino, D

The study concludes that this metabolic modulation represents a promising frontier for semaglutide