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Activated M1 macrophages generate high levels of ROS through inducible nitric oxide synthase (iNOS) and NADPH oxidases, while secreting cytokines such as TNF- and IL-1 that exacerbate mitochondrial membrane potential loss and activate inflammasome pathways [49]

[PMID: 4028290] PubMed record related to this compound for laboratory literature review

Strawn JR, DAlessio DA, Keck PE, Seeley RJ

If you have sensitive skin or a history of allergic reactions, discuss this with your doctor