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This reduction in glutathione means free radicals build up and damage the liver cells

Why are GLP-1 drugs used in type 2 diabetes

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The timing question that applies to GLP-1 medications broadly applies here as well, and the answer is largely personal preference

CAFs upon activation secretes growth factors, cytokines, and ECM molecules including TGF-, matrix metalloproteinases (MMPs), hepatocyte growth factor (HGF), and fibroblast growth factors (FGFs), which are implicated in tumor development, invasion, and metastasis (120)

PMID 15792952