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It may be considered in the context of shared decision making, particularly for families who have exhausted established evidence based interventions, while larger and more rigorous clinical trials are awaited

Readers familiar with how cholesterol research reshaped cardiovascular medicine over decades will recognize the significance of a single drug moving MACE outcomes by that margin

Figure 1 Weight Change GLP-1 + metformin showed the highest efficacy, resulting in a mean difference (MD) of 5.58 kg (95% CI: 8.57 to 2.59, p = 0.0003) compared to placebo ( Figure 2 )

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This provides metabolic support without aggressive intervention

Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects