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Contraindications include: The American Academy of Pediatrics guidelines mark a shift in obesity management: Pharmacotherapy may be offered alongside lifestyle modifications at initial presentation, rather than after other approaches have failed

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"Mitochondrial dysfunction and insulin resistance." Endocrinology 2020;161:bqaa017

Evaluating semaglutide and tirzepatide in early non-responders While semaglutide produces 15-17% mean weight loss and tirzepatide yields even more impressive 16-22.5% reductions, neither has been thoroughly evaluated in early non-responders